Since Chemistry is largely about changes in which starting materials react together to give products, it is important to know which bonds are strong and which are weak. It should make sense that it is desireable to swap weaker bonds for stronger, more stable bonds. In General Chemistry we learn about Hess’s Law in which known bond strengths from other reactions may be used to calculate what will happen in new situations. We can do the same in Organic Chemistry if we know some generalities; ionic bonds are strong as always, and within covalent bonds the strength depends on factors such as dipolar character, relative atom size, and the presence of adjacent lone pairs. While we don’t do as many of this type of calculation in Organic, we do benefit from having an appreciation of what makes bonds strong or weak. Examples are shown below; clicking on the image will take you to a more extensive discussion from LibreTexts.

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Application to Organic Molecules

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Where does Negative Charge want to be?